She is Lestat de Lioncourt's mother and first fledgling. She had yellow-blond hair like her son's and cobalt blue eyes with "too small, too kittenish" features, as Lestat described them, that "made her look like a girl."

Lestat was now the maker, parent, and teacher, while Gabrielle became the fledgling, the child and the student. Lestat took her to his tower where they lived happily for months. Things changed, however, when Lestat destroyed the Satanic cult headed by Armand, founded a theater and made Nicolas de Lenfent into a vampire. After this, Lestat and Gabrielle went traveling around the world. Gabrielle became increasingly distant and cold to her son. They finally parted in Egypt just after the French Revolution. Gabrielle went into the deep jungles of Africa and Lestat went underground to sleep for two years.
Gabrielle was off exploring the world on her own for the next 200 years. She did not reappear until 1985 (during The Queen of the Damned.) She was there to help her son fight against Akasha and help save the world. During this time, she developed a slight bond with Marius, but nothing became of it and she drifted away from everyone again. Gabrielle resurfaced for the last time after Memnoch the Devil, in The Vampire Armand while Lestat was in his catatonic sleep.