Cameron Brown attended Christian Brothers College High School and was rated a 4-star prospect by 247 Sports with a scout's rating of 0.897, going unranked by ESPN. Following high school, Brown opted to join Ohio State after being heavily recruited.

In 2018 as a freshman Brown saw action in just 3 games and played a total of 24 snaps at cornerback for the Buckeyes. He recorded just one tackle, no assists, while adding no stops. In coverage Brown notched up no pass breakups, no interceptions, and an elite QB rating when targetted of 39.6.

As a sophomore in 2019 he played in 14 games and logged 255 snaps for the Buckeyes. He made 11 tackles, 3 assists, and had 7 stops. In coverage he totaled no pass breakups, no interceptions, and an impressive QB rating when targetted of 68.3.

In 2020 as a junior Brown played in just 2 games and contributed on 40 snaps. He chalked up just one tackle, no assists, and added no stops. In the secondary Brown forced no pass breakups, no interceptions, and gave up an elite QB rating when targetted of 39.6.

In 2021 as a senior Brown saw action in 11 games while playing 456 snaps. He logged 20 tackles, 6 assists, and made 5 stops. In coverage Brown had 6 pass breakups, one interception, and surrendered an elite QB rating when targetted of 44.9.

In 2022 as a fifth year senior Brown saw action in 7 games while playing 256 snaps. He logged 11 tackles, 2 assists, and made 4 stops. In coverage Brown had 4 pass breakups, no interceptions, and surrendered a disapointing QB rating when targetted of 140.1.