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Susie Derkins is a classmate of Calvin who lives in his neighborhood. In contrast to Calvin she is polite and diligent in her studies, and her imagination usually seems mild-mannered and civilized, consisting of games such as playing "house" or having tea parties with her stuffed animals.
Susie and Calvin's relationship is a constant source of tension; she is frequently the victim of Calvin's derision and plots, and is also often willing to retaliate when provoked. Most commonly, Susie will be the target of Calvin's water balloons or snowballs, and he often goes to great lengths to disgust or annoy Susie. Calvin founded his and Hobbes' secret club, G.R.O.S.S. (Get Rid Of Slimy GirlS) as a general anti-girl organization, but in practice the club is almost invariably dedicated to pestering Susie specifically.
On occasion, Hobbes takes action to attract Susie's romantic attention, often with success, and much to Calvin's chagrin. Although on the surface these scenarios take the form of Hobbes teasing Calvin and showing off his charms, they may be Calvin's way to disguise his own crush on Susie, by pretending that it is Hobbes' crush instead. As Calvin once said, "It's shameless the way we flirt."