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Paul Sheldon is the writer of the very successful "Misery" series of romance novels. When he is injured in a car accident, he is taken in by Annie Wilkes.
His legs are injured, and he cannot walk. At first Annie, who says she is a nurse, seems to have Paul's best interests in mind. She brings him painkillers, feeds him, and rants on and on about how she is 'his number one fan'.
But it soon becomes clear that Annie is mentally unbalanced.