A statuesque blonde, Isobel "Izzie" Stevens put herself through medical school by modeling. Underwear. Wow.

When this fact is publicized by Dr. Alex Karev, who pins pictures of her up in the locker room, Izzie flys off the handle. She later warms up to Alex, however, and dates him briefly before catching him sleeping with a nurse and breaking it off.

At first, Izzie butted heads with Meredith over the latter's relationship with Dr. Shepherd. Izzie initially believed it was a plot for Dr. Grey to get ahead of her fellow interns, but the two have become good friends. They live in the same house, one that was also inhabited by George until the most recent episode.

When meeting a pregnant teenage girl from her hometown (outside Seattle), Izzie revealed that she, too, had a daughter at 16. Her daughter, who is now 12, was adopted and now lives in Santa Barbara, Calif. Izzie has shown an interest in surgery involving infants and extremely young children, the specialty of Dr. Addison Shepherd.

Fell in love with everyone's favorite patient, Denny, before he died from heart failure. In her illegal attempt to save him, Izzie risked her entire medical career.