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[R]
Organic Mayhem
Pyripyropene A
#2
Chosen Blocker
MA
5
ST
4
AG
3
AV
9
R
21
B
64
P
1
F
0
G
13
Cp
2
In
0
Cs
2
Td
1
Mvp
1
GPP
14
XPP
0
SPP
14
Injuries
Skills
Block (20k)
The introduction of an article about pyripyropenes:" Fungal metabolite pyripyropenes isolated from Aspergillusfumigatus FO- 1289 were originally found to be
potent acyl-CoA : cholesterol acyltransferase (ACAT) inhibitors. During studies on chemical modification and structure-activity relationships of pyripyropenes to develop potent ACAT inhibitors, more than 300 derivatives were synthesized. Recently, Wang et al. reported that pyripyropene A (1) was obtained from a metabolite of Eupenicillium reticulisporum NRRL3446 in the course of antiinsectan screening. Furthermore, structurally related analogs of 1 were presented as microtuble-disrupting anticancer drugs. Herein we describe the potential in reversing multidrug resistance (MDR) by pyripyropene
derivatives in drug-resistant cells."
The article is from The journal of antibiotics, 2000, 422-425 by Obata.
potent acyl-CoA : cholesterol acyltransferase (ACAT) inhibitors. During studies on chemical modification and structure-activity relationships of pyripyropenes to develop potent ACAT inhibitors, more than 300 derivatives were synthesized. Recently, Wang et al. reported that pyripyropene A (1) was obtained from a metabolite of Eupenicillium reticulisporum NRRL3446 in the course of antiinsectan screening. Furthermore, structurally related analogs of 1 were presented as microtuble-disrupting anticancer drugs. Herein we describe the potential in reversing multidrug resistance (MDR) by pyripyropene
derivatives in drug-resistant cells."
The article is from The journal of antibiotics, 2000, 422-425 by Obata.
Match performances
Date
Opponent
Comp
TD
Int
Cas
Mvp
Spp
2009-02-21
-
-
-
2
-
4
2009-02-22
1
-
-
-
-
1
2009-02-24
1
-
-
-
-
1
2009-02-25
-
1
-
-
-
3
2009-02-27
-
-
-
-
1
5