In 2002, with support from her brother, Lisa sought, and gained employment with Umbrella, assigned to the computer security division working out of The Hive. The purpose of this being to recover incriminating evidence of Umbrella's crimes, a task she was well suited to. She was forced to work closely with Dr. Barr's creation, the Red Queen, and found that duty quite unpleasant.

While in the Hive, Lisa created a security protocol requiring all employees to change their password for the computer network every eight days. She knew that most people would forget, which was another part of her plan. When someone forgot to change their password, they were locked out of the system until Lisa could help them. After resetting their password, Lisa would get a momentary glance at whatever information the person in question was trying to access, in the few seconds it took the Red Queen to realize that she didn't have clearance to see the data. It was this method by which Lisa hoped to secure the evidence against Umbrella. It was also by this method that she came to conspire with Alice.