Originally a normal scientist and ambitious businessman, Norman Osborn uses an experimental formula which gives him superpowers but also drives him insane. When Spider-Man thwarts his plans to take over as crime boss of New York City, he dedicates himself to utterly destroying Spider-Man's life. Their mutual animosity becomes personal when Osborn kills Gwen Stacy, Parker's long-time girlfriend and first true love. He is generally acknowledged to be Spider-Man's arch-nemesis and worst enemy, and also is responsible for the murder of Ben Reilly, the disappearance of Peter Parker's infant daughter, his son Harry's spiral into madness and eventual death, and masterminding the entire Clone Saga.