"Dr. Thrax": The GLA Toxin General's units and some structures are boosted with toxins, and he sacrifices very little for his tactical advantages when fully upgraded. Most notable of advantages, is the fact that his units are granted the more potent toxin, Anthrax Beta (a late-game upgrade) from the beginning of a match, and can upgrade with Anthrax Gamma (Anthrax Gamma is an effective weapon that can destroy tanks), to improve his forces further. He is able to train Toxin Rebels. The toxin-dispensing weapons of these units are equally effective against vehicles and infantry. His Tanks, RPG infantry and Stinger Sites also add a "stream" of toxin to their rockets, which adds a large damage bonus to their attacks.

General Ta Hun Kwai: Kwai's general strategy is focused on the use of heavily armored, technologically superior tanks and vehicles. He is unable to build artillery units and must pay more to deploy aircraft and infantry. He has cheaper and more powerful tanks. Strategies involving reliance on heavy vehicle assaults and rapid troop movements are suited to General Kwai's forces. However, the overall lack of long-ranged support units leave Kwai's forces vulnerable to long range bombardment, against which his forces cannot effectively retaliate.

General Tsing Shi Tao: Tao's army is boosted by nuclear energy. His nuclear technology enables more output per power plant than that of other Chinese divisions. He also utilizes a nuclear arsenal via missile silos, tactical nuclear artillery, and nuclear bomb equipped MiG fighter jets and Helix helicopters. His Overlord and Battlemaster Tanks fire shells that release nuclear radiation. In addition, their movement speed is much greater than that of standard Chinese tanks. Other than these additions, there are no significant changes, and Tao's forces play much like the mainstream Chinese Army.

General "Anvil" Shin Fai: "Anvil" specializes in infantry units and has a significant early tactical advantage against the infantry of other Generals. All infantry under his command start as veterans; He also can requisition elite Minigunners to replace the standard Red Guardsmen. These high-caliber weapons they carry are the bane of aircraft in larger numbers. However, he is unable to build heavier battle tanks, but is still able to deploy primarily anti-personnel and support vehicles. This reliance on infantry leaves his force very vulnerable to the effects of radiation and toxins; and under less common circumstances, mass vehicle rushes, where infantry are vulnerable to being run over, yet, if his abilities and advantages are used properly and efficiently, will bring swift defeat to opposing forces. He is not faced in the General's Challenge.

Prince Kassad: A GLA General specializing in stealth tactics. All of his buildings can be covered in camo netting, making them invisible to most enemy units, he gets an improved GPS Scrambler ability, allowing him to cloak more units than other GLA cells can in a period of time, and has improved stealth Rebels. He also has cheaper Hijackers from the start that are always stealthed. He cannot build main battle tanks, or long range SCUD launchers. Ambush, surprise, harassment and attrition are the optimal strategies for Kassad's forces. However, the lack of heavy armor leaves them even more vulnerable than regular GLA cells to direct and concentrated assaults. Also, the inability to deploy long range SCUD launchers means that at most times, his forces operate without in-direct fire support. The stealthy presence of his forces provide a psychological edge over human opponents, but AI can somewhat detect the player's presence without using satellite scans or other stealth-detecting devices.

General Rodall "Demo" Juhziz: A GLA general specializing in explosives. Most of his field units and buildings are granted a self-destruct capability, encouraging the use of suicide attacks. His Terrorists are more powerful and he has cheaper, more powerful Demo Traps. His Combat Cycles come with a Terrorist instead of a Rebel. He does not have access to most stealth units or Anthrax weapons. He also does not face the player in the Generals' Challenge.

General Townes: Townes' strategy is focused on using laser weaponry. His power plants cost less and generate more energy. This general does not have access to the Paladin tank or the Tomahawk. It is also worth noting that his Laser crusaders require one point of power each. Strategies include building power plants and then laser defense turrets to destroy most forces that close in on his base. When attacking, use Comanches and infantry to support your laser tanks. His defenses are vulnerable to artillery like the nuke cannon, tomahawk and so on.

General Malcolm "Ace" Granger: Granger's strategy is focused on more powerful aircraft. His aircrafts are slightly cheaper and feature a laser defense system (this includes all aircraft barring the Comanche). One possible strategy is to attack the enemy's base with an onslaught of fully-upgraded King Raptors. However, his air forces are vulnerable to anti-air defenses. When countering this general be sure to build a large group of anti-air units. Using artillery is a good way to defeat him.

General Alexis Alexander: Alexander's strategy is focused on super weapons. Alexander can create a very stable economy and build up a large amount of special weapons and defensive structures quicker than most generals. The price of the particle cannon is slashed in half for her, $2500 instead of the usual $5000.

General "Tigress" Leiong Leang: The final general in the Generals' Challenge. She has a massive army consisting of units & structures from all three regular factions, in addition to a Particle Cannon, Nuclear Missile, and Scud Storm. She is not a playable general. However, she can be unlocked as a playable general in different incarnations by several modifications.

eneral Ironside is the boss general of the USA forces alongside the American Commander.

He utilizes all powers available to USA faction, such as the combination of the effective King Raptor, deadly Aurora Alpha and cheap Particle Cannon. both EMP Patriot Missile Defense and Laser Turret is available, make his base is nearly impenetrable. Besides that, he also uses a group of CIA agents which can plant demolitions, assisted by few Pathfinders which always cloaked led by Colonel Burton which can plant bombs even faster.

General Mohmar "Deathstrike" the boss general of the GLA forces, he is never fought, but he is the focus in first mission of the GLA campaign. In that mission, Deathstrike must be escorted to a stolen C-130.

The United States is the most technologically-advanced faction, and fights with a combination of powerful ground units and a large, versatile fleet of aircraft. USA forces rely on skill, mobility, and high technology to defeat the raw firepower of China and the guerrilla tactics of the GLA. USA ground vehicles can construct unmanned drones to support and repair them in combat, while American troops and vehicles make extensive use of laser technology to guide weapons and defend against attack. American infantry have a number of special abilities, and include stealthy long-ranged snipers called Pathfinders and a powerful commando named Colonel Burton with a number of abilities revolving around demolition and stealth. The USA also fields the largest air fleet in the game, including attack and transport helicopters, fighter planes, high speed bombers and stealth bombers. American Generals' abilities revolve around air power, including air strikes by A-10 Thunderbolts and fuel air bombs (a.k.a The Daisy Cutter). They also possess a Particle Cannon super weapon capable of destroying units and most buildings in a single use.

The People's Republic relies largely on brute force and sheer numbers, culminating in a variety of powerful and heavily armored tanks, and has limited air power. China's play style emphasizes direct assaults and sheer power to defeat American technology and GLA stealth, and also places some emphasis on defense. Combining Bunkers fully loaded with Tank Hunter for engaging tanks and Gattling Cannons to kill infantry and aircraft easily defend against any attack. In addition, Chinese buildings can be surrounded by Land Mines to prevent infiltration. Chinese troops and tanks gain special bonuses when in groups, and make extensive use of propaganda (passive healing) to support their troops. China has a wide range of vehicle types, including several specialized tanks like Type 88 as "Battlemaster", BTR-80 as "Troop Crawler", "Overlord" tank(s) and two artillery units. China make heavy use of gattling, nuclear, and napalm weaponry to destroy the enemy, but also posses advanced electronic warfare technology, including elite hackers, a spy called Black Lotus, and electromagnetic pulse weapons. The Chinese "Inferno Cannon" and "Nuke Cannon" are the only artillery units whose shells cannot be intercepted.

Being technologically disadvantaged, the Global Liberation Army has comparatively weak (though highly mobile) ground vehicles and no air force, prompting the use of guerrilla tactics such as mining, suicide bombing, hijacking, and appropriating enemy resources.

The GLA has a larger array of infantry types and vehicles to make up for their disadvantages, and also has the widest range of stealth options. In addition, the GLA has a very powerful economy, with various resource-gathering techniques such as salvaging wreckage, gaining cash bounties on destroyed enemy units, and building multiple "black market" structures to bring in large amounts of money over time. Also, the GLA are unique in that they have no energy requirement for any of their structures or units. GLA units have a multitude of upgrades that significantly increase their power as they become fully equipped, transforming a relatively weak group of units into a more respectable threat. The GLA is also unique in that its structures, particularly base defenses, rebuild themselves over time unless completely destroyed; this makes it difficult to permanently damage the GLA with many single-shot weapons or units.

The GLA's toxic weapons, suicide units, and stealth and surprise abilities enable it to hit enemies from unexpected directions, and its powerful economy, combined with cheap, fast units, enables it to flood opponents with sheer numbers. The GLA's primary disadvantage is that it lacks firepower, range, and durability as well as power, except one plane to send Anthrax Bombs. This forces a GLA player to outmaneuver or outnumber opponents, as in an even, direct confrontation the GLA will lose to superior Chinese firepower and American technology. Despite lacking any aircraft units the GLA has the most feared anti-aircraft unit, the Quad Cannon. A medium armored truck, the Quad Cannon is effective against aircraft, with a fully upgraded quad cannon being one of the greatest surface threats to air units.