Lestat de Lioncourt was born in 1760. He has long, pale blond hair, and blue eyes that frequently appear gray when reflecting light. In 1779, he flees to Paris with his friend Nicholas to become an actor. There, an old vampire named Magnus ambushes him and makes him into a vampire against his will. Then, after teaching Lestat nothing, Magnus hurls himself into a huge bonfire telling Lestat to scatter the ashes else he will rise again and destroy Lestat. He is the narrator of five of the books in the Chronicles, in which he portrays himself as the hero. His fledglings are Gabrielle, Nicholas, Louis, Claudia, the musician, David, and Mona Mayfair. In [[Interview with the Vampire]] when Louis returns to New Orleans and finds Lestat in the remains of their old flat, Lestat is accompanied by another fledgling which is never named or elaborated on or re-introduced. Lestat is bold, brash, impulsive, fearless, and lives without regret, and contrasts strongly both physically and in personality with Louis.

Louis de Pointe du Lac was born in New Orleans in 1766, and was made into a vampire by Lestat in 1791. He has glossy black hair and glittering green eyes. Anne Rice wrote Interview with the Vampire after the death of her daughter, and Louis, as the main character, is portrayed as melancholic and depressive as a projection of Rice's own feelings at the time. He displays emotion that is uncommonly human for a vampire, and feels moral remorse in killing humans when he feeds. Louis, faithful, passive and frequently displaying weakness, strongly contrasts against Lestat.

Played by Jeanette Kontomitras

Played by Lyla Hay Owen

Daniel Molloy is a reporter who records Louis' life story. He has ash-blond hair and violet eyes and looks young and boyish for his age. After the interview, he wants to become a vampire, feeling that Louis wastes his "gift."

Played by Laure Marsac

Plantation Overseer played by Danny Kamin

Played by Lee E. Scharfstein

Played by Thandie Newton

Played by Bellina Logan

Played by Mike Seelig

Played by John McConnell

Played by Nathalie Bloch-Lainé