not related to the Ventures per se, Brock is the bodyguard of the Venture family and an agent with the Office of Secret Intelligence. As a "Super Secret Agent," he has a license to kill and an amazing zeal to use it. His background has been revealed to be "half Swedish, quarter Polish, quarter Winnebaego". Though Brock usually displays a relaxed and casual attitude, his temper can cause him to snap into psychotic violence at the slightest provocation. His ability to dispense punishment is equaled by his ability to sustain it, to the point that he is seemingly unkillable. He also has a superhuman sexual appetite, with conquests ranging from beauty queens to sleazy strippers to "the Queen of the Ant People." He is extremely loyal to the Venture family, actually living with them in the compound, and now seems to serve as a bit of a mentor for the boys, with whom he shares an avuncular relationship.

The Venture family's personal helper robot. H.E.L.P.eR. is an acronym for Humanoid Electric Lab Partner Robot. He was created by Dr. Jonas Venture to look after his son Rusty, but now assists Brock in looking after Dean and Hank. He does not speak, but rather communicates via electronic beeps that are more or less understood by the Venture clan. Though he has very sensitive feelings, the Ventures often treat him like an old appliance or pet.

Colonel Horace Gentleman† (voiced by Christopher McCulloch): Retired member of the original Team Venture and later ersatz leader of the reformed Team Venture. He is a British gentleman and adventurer in the vein of Allan Quatermain and James Bond. The influence is apparent in the similarity of his voice to that of Sean Connery, who has played both characters in movies. He dresses in an old-fashioned British suit, complete with cane. It is briefly implied that he is a pederast and was later confirmed by the creators.[1] In the second season, Hank and Dean find him dead of unspecified causes. Apparently had a penchant for writing out random lists in his notebook such as "Toys Colonel Gentleman Wishes He Had When He Was a Lad but They Weren't Invented Yet." A deleted scene from the episode expands this list, and adds others.

Jefferson Twilight (voiced by Charles Parnell): An old friend of Dr. Orpheus. He is a black man who fights blaculas for a living and wields two swords. He is a pastiche of the superhero Blade and the blaxploitation movie protagonist, Shaft. His look and voice are also heavily based on Samuel L. Jackson. As a play on Blade's half-vampire thirst for blood or an artificial replacement, Jefferson Twilight suffers from diabetes and low blood-sugar, leading him to heavily thirst for sugared liquids, such as Nik-L-Nips.

A self-proclaimed "boy genius," Quizboy is actually an adult with a speech impediment and growth hormone deficiency. He is a neurogeneticist and co-founder of Conjectural Technologies. He suffers from hydrocephalus, although his intellect seems to be unaffected by this condition. He has a bionic hand and wears an eyepatch over one eye, which are the unspecified result of a heavily rumored incident that also left Phantom Limb without his appendages, although Billy seems to have no memory of the incident. He is a virgin.

An albino computer scientist and co-founder of Conjectural Technologies. He went to college with Venture and Ünderbheit where he hosted a New Wave radio show called "The White Room." Like Venture and Quizboy, White tends to be somewhat lazy and half-hearted in his efforts. On occasion, characters refers to him as "the gay albino", although it is unlikely that he is really gay.

Kano (unvoiced): Retired member of the original Team Venture. He is a master of the martial arts and an accomplished pilot. He never speaks, and only communicates by way of origami and sparse gestures. As Col. Gentleman describes him, his hands are "powerful enough to crush a boulder, yet delicate enough to crush a butterfly." Although not a villain, his silent demeanor, fighting skills and brute strength all correspond with the bodyguard/henchman archetype found in many works of fiction, with particular similarities to Oddjob. Although a hulking, powerful fighter, he is still no match for Brock Samson, at least in his old age. In addition to his skill in fighting and origami, Kano also appears to be a capable aircraft pilot ("despite his racial handicap," according to Col. Gentleman).

The Action Man, whose real name is Rodney (voiced by Christopher McCulloch): Retired member of the original Team Venture. He is an all-American supersoldier reminiscent of a B-grade Nick Fury, though his costume evokes elements of a vintage Captain America. Since his retirement, he has become a crotchety old man with flatulence problems. He married Major Tom's widow, Jeannie, after Tom's tragic accident. It was implied in the episode "Ghosts Of the Sargasso" that he cheated with Genie before Tom's death (in a deleted scene from "Past Tense," Otto Aquarius directly refers to him as an adulterer); Tom himself bitterly remarks in the same Episode, "I'm Happy, Hope You're Happy Too", implying that he knew about and accepted the affair. Dr. Orpheus predicted that Action Man would have a fatal stroke two years and seventeen days after an accidental confrontation. The Action Man gets his name from the David Bowie song "Ashes to Ashes", which functioned as a follow-up to "Space Oddity", which introduced "Major Tom"