Leonardo di ser Piero da Vinci , April 15, 1452 – May 2, 1519 was an Italian polymath; a scientist, mathematician, engineer, inventor, anatomist, painter, sculptor, architect, botanist, musician and writer. Born as the illegitimate son of a notary, Piero da Vinci, and a peasant girl, Caterina, at Vinci in the region of Florence, Leonardo was educated in the studio of the renowned Florentine painter, Verrocchio. Much of his earlier working life was spent in the service of Ludovico il Moro in Milan. He later worked in Rome, Bologna and Venice, spending his final years in France at the home given to him by King François I.

Leonardo has often been described as the archetype of the "Renaissance man", a man whose seemingly infinite curiosity was equalled only by his powers of invention. He is widely considered to be one of the greatest painters of all time and perhaps the most diversely talented person ever to have lived.

It is primarily as a painter that Leonardo was and is renowned. Two of his works, the Mona Lisa and The Last Supper occupy unique positions as the most famous, most reproduced and most parodied portrait and religious painting of all time, their fame approached only by Michelangelo's Creation of Adam. Leonardo's drawing of the Vitruvian Man is also iconic. Perhaps fifteen of his paintings survive, the small number due to his constant, and frequently disastrous, experimentation with new techniques, and his chronic procrastination. Nevertheless, these few works together with his notebooks, which contain drawings, scientific diagrams, and his thoughts on the nature of painting, comprise a contribution to later generations of artists only rivalled by that of his contemporary, Michelangelo.

As an engineer, Leonardo's ideas were vastly ahead of his time. He conceptualised a helicopter, a tank, concentrated solar power, a calculator, the double hull and outlined a rudimentary theory of plate tectonics. Relatively few of his designs were constructed or were even feasible during his lifetime,but some of his smaller inventions, such as an automated bobbin winder and a machine for testing the tensile strength of wire, entered the world of manufacturing unheralded. As a scientist, he greatly advanced the state of knowledge in the fields of anatomy, civil engineering, optics, and hydrodynamics.

Gottfried Wilhelm Leibniz (also Leibnitz or von Leibniz (July 1 (June 21 Old Style) 1646 – November 14, 1716) was a German polymath who wrote primarily in Latin and French.

He occupies an equally grand place in both the history of philosophy and the history of mathematics. He invented calculus independently of Newton, and his notation is the one in general use since then. He also discovered the binary system, foundation of virtually all modern computer architectures. In philosophy, he is mostly remembered for optimism, i.e. his conclusion that our universe is, in a restricted sense, the best possible one God could have made. He was, along with René Descartes and Baruch Spinoza, one of the three greatest 17th century rationalists, but his philosophy also looks back to the scholastic tradition and anticipates modern logic and analysis. Leibniz also made major contributions to physics and technology, and anticipated notions that surfaced much later in biology, medicine, geology, probability theory, psychology, linguistics, and information science. He also wrote on politics, law, ethics, theology, history, and philology, even occasional verse. His contributions to this vast array of subjects are scattered in journals and in tens of thousands of letters and unpublished manuscripts. To date, there is no complete edition of Leibniz's writings.

Johann Wolfgang von Goethe (28 August 1749 – 22 March 1832) was a German writer. George Eliot called him "Germany's greatest man of letters… and the last true polymath to walk the earth."] Goethe's works span the fields of poetry, drama, literature, theology, humanism, and science. Goethe's magnum opus, lauded as one of the peaks of world literature, is the two-part drama Faust. Goethe's other well-known literary works include his numerous poems, the Bildungsroman Wilhelm Meister's Apprenticeship and the epistolary novel The Sorrows of Young Werther.

Goethe was one of the key figures of German literature and the movement of Weimar Classicism in the late 18th and early 19th centuries; this movement coincides with Enlightenment, Sentimentality (Empfindsamkeit), Sturm und Drang, and Romanticism. The author of the scientific text Theory of Colours, he influenced Darwin with his focus on plant morphology. He also long served as the Privy Councilor ("Geheimrat") of the duchy of Weimar.

Goethe is the originator of the concept of Weltliteratur ("world literature"), having taken great interest in the literatures of England, France, Italy, classical Greece, Persia, Arabic literature, amongst others. His influence on German philosophy is virtually immeasurable, having major impact especially on the generation of Hegel and Schelling, although Goethe himself expressly and decidedly refrained from practicing philosophy in the rarefied sense.

Goethe's influence spread across Europe, and for the next century his works were a major source of inspiration in music, drama, poetry and philosophy. Goethe is considered by many to be the most important writer in the German language and one of the most important thinkers in Western culture as well. Early in his career, however, he wondered whether painting might not be his true vocation; late in his life, he expressed the expectation that he would ultimately be remembered above all for his work in optics.

Charles Robert Darwin (12 February 1809 – 19 April 1882) was an English naturalist, eminent as a collector and geologist, who proposed and provided scientific evidence that all species of life have evolved over time from common ancestors through the process he called natural selection. The fact that evolution occurs became accepted by the scientific community and the general public in his lifetime, while his theory of natural selection came to be widely seen as the primary explanation of the process of evolution in the 1930's, and now forms the basis of modern evolutionary theory. In modified form, Darwin’s scientific discovery remains the foundation of biology, as it provides a unifying logical explanation for the diversity of life.

Darwin developed his interest in natural history while studying first medicine at Edinburgh University, then theology at Cambridge. His five-year voyage on the Beagle established him as a geologist whose observations and theories supported Charles Lyell’s uniformitarian ideas, and publication of his journal of the voyage made him famous as a popular author. Puzzled by the geographical distribution of wildlife and fossils he collected on the voyage, Darwin investigated the transmutation of species and conceived his theory of natural selection in 1838. Although he discussed his ideas with several naturalists, he needed time for extensive research and his geological work had priority. He was writing up his theory in 1858 when Alfred Russel Wallace sent him an essay which described a similar theory, prompting immediate joint publication of both of their theories.

His 1859 book On the Origin of Species established evolution by common descent as the dominant scientific explanation of diversification in nature. He examined human evolution and sexual selection in The Descent of Man, and Selection in Relation to Sex, followed by The Expression of the Emotions in Man and Animals. His research on plants was published in a series of books, and in his final book, he examined earthworms and their effect on soil.

In recognition of Darwin’s pre-eminence, he was buried in Westminster Abbey, close to John Herschel and Isaac Newton.

Sir Isaac Newton, 4 January 1643 – 31 March 1727 [OS: 25 December 1642 – 20 March 1726]) was an English physicist, mathematician, astronomer, natural philosopher, alchemist and theologian. His Philosophiæ Naturalis Principia Mathematica, published in 1687, is said to be the greatest single work in the history of science. In this work, Newton described universal gravitation and the three laws of motion, laying the groundwork for classical mechanics, which dominated the scientific view of the physical universe for the next three centuries and is the basis for modern engineering. Newton showed that the motions of objects on Earth and of celestial bodies are governed by the same set of natural laws by demonstrating the consistency between Kepler's laws of planetary motion and his theory of gravitation, thus removing the last doubts about heliocentrism and advancing the scientific revolution.

In mechanics, Newton enunciated the principles of conservation of momentum and angular momentum. In optics, he invented the reflecting telescope and developed a theory of colour based on the observation that a prism decomposes white light into a visible spectrum. He also formulated an empirical law of cooling and studied the speed of sound.

In mathematics, Newton shares the credit with Gottfried Leibniz for the development of calculus. He also demonstrated the generalized binomial theorem, developed the so-called "Newton's method" for approximating the zeroes of a function, and contributed to the study of power series.

In a 2005 poll of the Royal Society asking who had the greater effect on the history of science, Newton was deemed much more influential than Albert Einstein.

Galileo Galilei (15 February 1564 – 8 January 1642) was a Tuscan (Italian) physicist, mathematician, astronomer, and philosopher who played a major role in the scientific revolution. His achievements include improvements to the telescope and consequent astronomical observations, and support for Copernicanism. Galileo has been called the "father of modern observational astronomy", the "father of modern physics", the "father of science", and “the Father of Modern Science.” The motion of uniformly accelerated objects, taught in nearly all high school and introductory college physics courses, was studied by Galileo as the subject of kinematics. His contributions to observational astronomy include the discovery of the four largest satellites of Jupiter, named the Galilean moons in his honour, and the observation and analysis of sunspots. Galileo also worked in applied science and technology, improving compass design.

Galileo's championing of Copernicanism was controversial within his lifetime. The geocentric view had been dominant since the time of Aristotle, and the controversy engendered by Galileo's opposition to this view resulted in the Catholic Church's prohibiting the advocacy of heliocentrism as potentially factual, because that theory had no decisive proof and was contrary to the literal meaning of Scripture. Galileo was eventually forced to recant his heliocentrism and spent the last years of his life under house arrest on orders of the Inquisition.

Marie Curie (born Maria Sk?odowska; also known as Maria Sk?odowska-Curie; November 7, 1867 – July 4, 1934) was a physicist and chemist of Polish upbringing and, subsequently, French citizenship. She was a pioneer in the field of radioactivity, the first and only person honored with Nobel Prizes in two different sciences, and the first female professor at the University of Paris.

She was born in Warsaw, Vistulan Country, Russian Empire, and lived there until she was 24. In 1891 she followed her elder sister Bronis?awa to study in Paris, where she obtained her higher degrees and conducted her scientific work. She founded the Curie Institutes in Paris and Warsaw. She was the wife of fellow-Nobel-laureate Pierre Curie and the mother of a third Nobel laureate, Irène Joliot-Curie.

While an actively loyal French citizen, she never lost her sense of Polish identity. Madame Curie named the first new chemical element that she discovered (1898) "polonium" for her native country, and in 1932 she founded a Radium Institute (now the Maria Sk?odowska-Curie Institute of Oncology) in her home town, Warsaw, headed by her physician-sister Bronis?awa.

Albert Einstein ((March 14, 1879 – April 18, 1955) was a German-born theoretical physicist. He is best known for his theory of relativity and specifically mass–energy equivalence, E = mc2. Einstein received the 1921 Nobel Prize in Physics "for his services to Theoretical Physics, and especially for his discovery of the law of the photoelectric effect."

Einstein's many contributions to physics include his special theory of relativity, which reconciled mechanics with electromagnetism, and his general theory of relativity, which extended the principle of relativity to non-uniform motion, creating a new theory of gravitation. His other contributions include relativistic cosmology, capillary action, critical opalescence, classical problems of statistical mechanics and their application to quantum theory, an explanation of the Brownian movement of molecules, atomic transition probabilities, the quantum theory of a monatomic gas, thermal properties of light with low radiation density (which laid the foundation for the photon theory), a theory of radiation including stimulated emission, the conception of a unified field theory, and the geometrization of physics.

Einstein published over 300 scientific works and over 150 non-scientific works. Einstein is revered by the physics community, and in 1999 Time magazine named him the "Person of the Century". In wider culture the name "Einstein" has become synonymous with genius.