Nathan Explosion is the frontman, lead vocalist and "lyrical visionary" of Dethklok. Portrayed as a tall figure, with long black hair and black fingernails, Nathan always speaks in a deep, gravelly voice, even when not singing. He is apparently the lead songwriting force in Dethklok, and uses violent imagery or plot elements when writing and composing song material.

Toki Wartooth is Dethklok's rhythm guitarist. He typically plays a Gibson Flying V. A native of Norway, he has a distinct whisker-like style of mustache known as the Fu Manchu, long brown hair and very pale blue eyes.

Small explained Toki's relationship with Skwisgaar thusly: "Toki is Norwegian to Skwisgaar's Swedish, pompous attitude. And, again, a second-class citizen in the same band."

Skwisgaar Skwigelf is Dethklok's lead guitarist. He is described as, "a handsome guy who thinks he's the greatest thing in the world, with a little bit of Yngwie Malmsteen in his attitude."
He has long blond hair and blue eyes, and plays a Gibson Explorer, which he often carries around even when not playing. Hailing from Sweden, Skwisgaar possesses a heavy Swedish accent. He is responsible for the majority of the arrangement of Dethklok's songs, writing both the guitar lines as well as Murderface's bass lines.

Pickles is Dethklok's drummer. He was raised in Tomahawk, Wisconsin and speaks with a Yooper dialect. He refers to himself as "very Irish American" and has red hair, styled into dreadlocks and a comb-over skullet. He is depicted as having an average build with a slight beer belly.
Describing the character, Small said, "I thought the drummer should be able to do a bunch of stuff, like Roger Taylor in Queen. Even though it's not based on his personality, it's what he can do in the band and what parts of the songs he does contribute to."

William Murderface is Dethklok's bassist. He plays a Gibson Thunderbird Studio 5-string. He has brown hair, lime green eyes, a heavy lateral lisp and a diastema. Murderface's father killed his wife with a chainsaw before turning it upon himself in front of Murderface in a grisly murder-suicide. Murderface is "a self-hating bass player who's always trying to act like he's more important than he is," in part because his bass playing is usually mixed out completely.