Frederick Walter Stephen West (29 September 1941 – 1 January 1995), was a British serial killer. Between 1967 and 1987, he alone, and later, he and his wife Rosemary, tortured, raped and murdered at least 11 young women and girls, many at the couple's homes. Rosemary West also murdered Fred's stepdaughter (his first wife's biological daughter) Charmaine, while he was serving a prison sentence for theft. The majority of the murders occurred between May 1973 and September 1979 at their home in 25 Cromwell Street, Gloucester. The house was demolished in 1996 and the space converted into a landscaped footpath connecting Cromwell Street to St. Michaels Square.

Harold Fredrick Shipman (14 January 1946 – 13 January 2004) was an English doctor and one of the most prolific serial killers in recorded history with 218 murders being positively ascribed to him.

On 31 January 2000, a jury found Shipman guilty of 15 murders. He was sentenced to life imprisonment and the judge recommended that he never be released.

After his trial, the Shipman Inquiry, chaired by Dame Janet Smith, investigated all deaths certified by Shipman. About 80% of his victims were women. His youngest victim was a 41-year-old man. Much of Britain's legal structure concerning health care and medicine was reviewed and modified as a direct and indirect result of Shipman's crimes, especially after the findings of the Shipman Inquiry, which began on 1 September 2000 and lasted almost two years. Shipman is the only British doctor who has been found guilty of murdering his patients.

Shipman died on 13 January 2004, after hanging himself in his cell at Wakefield Prison in West Yorkshire.

Peter William Sutcliffe (born 2 June 1946) is a British serial killer who was dubbed "The Yorkshire Ripper". In 1981 Sutcliffe was convicted of murdering 13 women and attacking seven others. He is currently serving 20 sentences of life imprisonment in Broadmoor Hospital. After his conviction, Sutcliffe began using his mother's maiden name and became known as Peter William Coonan. The High Court dismissed an appeal in 2010, confirming that he would serve a whole life tariff and would never be released from imprisonment.

John George Haigh (24 July 1909 – 10 August 1949), commonly known as the "Acid Bath Murderer", was an English serial killer during the 1940s. He was convicted of the murders of six people, although he claimed to have killed nine. He did not use acid actually to kill his victims, but rather as (he believed) a foolproof method of body disposal – dissolving their bodies in concentrated sulphuric acid before forging papers in order to sell their possessions and collect substantial sums of money. During the investigation, it became apparent that Haigh was using the acid to destroy victims' bodies because he misunderstood the term corpus delicti, thinking that if victims' bodies could not be found, then a murder conviction would not be possible. The substantial forensic evidence, notwithstanding the absence of his victims' bodies, was sufficient for him to be convicted for the murders and subsequently executed.

Michael Lupo (1953 – 12 February 1995) was a serial killer originally from Italy, operating in Britain. He was based at the YSL boutique in Brompton Road, London during the 1980s.

The Moors murders were carried out by Ian Brady and Myra Hindley between July 1963 and October 1965, in and around what is now Greater Manchester, England. The victims were five children aged between 10 and 17—Pauline Reade, John Kilbride, Keith Bennett, Lesley Ann Downey and Edward Evans—at least four of whom were sexually assaulted. The murders are so named because two of the victims were discovered in graves dug on Saddleworth Moor, with a third grave also being discovered there in 1987, over 20 years after Brady and Hindley's trial in 1966. The body of a fourth victim, Keith Bennett, is also suspected to be buried there, but despite repeated searches it remains undiscovered.

The police were initially aware of only three killings, those of Edward Evans, Lesley Ann Downey, and John Kilbride. The investigation was reopened in 1985, after Brady was reported in the press as having confessed to the murders of Pauline Reade and Keith Bennett. Brady and Hindley were taken separately to Saddleworth Moor to assist the police in their search for the graves, both by then having confessed to the additional murders.

Characterised by the press as "the most evil woman in Britain", Hindley made several appeals against her life sentence, claiming she was a reformed woman and no longer a danger to society, but she was never released. She died in 2002, aged 60. Brady was declared criminally insane in 1985, since when he has been confined in the high-security Ashworth Hospital. He has made it clear that he never wants to be released, and has repeatedly asked that he be allowed to die.

The murders, reported in almost every English-language newspaper in the world, were the result of what Malcolm MacCulloch, professor of forensic psychiatry at Cardiff University, called a "concatenation of circumstances", which brought together a "young woman with a tough personality, taught to hand out and receive violence from an early age" and a "sexually sadistic psychopath".

Dr. Thomas Neill Cream (27 May 1850 – 15 November 1892), also known as the Lambeth Poisoner, was a Scottish-born serial killer, who claimed his first proven victims in the United States and the rest in England, and possibly others in Canada and Scotland. Cream, who poisoned his victims, was executed after his attempts to frame others for his crimes brought him to the attention of London police.

Unsubstantiated rumours suggested his last words as he was being hanged were a confession that he was Jack the Ripper—even though he was in prison at the time of the Ripper murders.

Robin Stanislaw Ligus, is a serial killer, who operated in Shropshire, killing three men in 1994. In 2011 he was ordered to be detained indefinitely in a secure mental hospital, as he is suffering from the effects of a stroke.

William Palmer (6 August 1824 – 14 June 1856), also known as the Rugeley Poisoner or the Prince of Poisoners, was an English doctor found guilty of murder in one of the most notorious cases of the 19th century. He was convicted for the 1855 murder of his friend John Cook, and was executed in public by hanging the following year. He had poisoned Cook with strychnine, and was suspected of poisoning several other people including his brother and his mother-in-law, as well as four of his children who died of "convulsions" before their first birthdays. Palmer made large sums of money from the deaths of his wife and brother after collecting on life insurance, and by defrauding his wealthy mother out of thousands of pounds, all of which he lost through gambling on horses.

Trevor Joseph Hardy (born c. 1945-died September 25, 2012), also known as the Beast of Manchester, was a convicted British serial killer who murdered three teenage girls in the Manchester area between December 1974 and March 1976. In 1977, he was found guilty and was sentenced to life imprisonment.

Robert Clive Napper (born 25 February 1966) is a convicted British serial killer and rapist who was remanded in Broadmoor Hospital indefinitely on 18 December 2008 for the manslaughter of Rachel Nickell on 15 July 1992. He was previously convicted of the 1993 double murder of Samantha Bisset and her daughter Jazmine.

He is a paranoid schizophrenic who has also been diagnosed with Asperger's syndrome.