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Doctor Octopus (real name Otto Octavius) is a comic book supervillain in the Marvel Comics universe (created by Stan Lee and Steve Ditko) and one of the greatest foes of Spider-Man. "Doc Ock", as Spider-Man often calls him, is a powerful and highly intelligent foe who is usually considered Spider-Man's worst enemy, alongside the Green Goblin; a position not contested until the late 1980s by Venom. The character's first appearance was in Amazing Spider-Man volume 1 #3 (July 1963).